Browsing by Author "Matarazzo, Jerico V"

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    Combined optogenetic and electrical stimulation of the sciatic nerve for selective control of sensory fibers.
    (Frontiers in Neuroscience, 2023-06-08) Matarazzo, Jerico V; Ajay, Elise A; Payne, Sophie C; Trang, Ella P; Thompson, Alex C; Marroquin, Jason B; Wise, Andrew K; Fallon, James B; Richardson, Rachael T
    Electrical stimulation offers a drug-free alternative for the treatment of many neurological conditions, such as chronic pain. However, it is not easy to selectively activate afferent or efferent fibers of mixed nerves, nor their functional subtypes. Optogenetics overcomes these issues by controlling activity selectively in genetically modified fibers, however the reliability of responses to light are poor compared to electrical stimulation and the high intensities of light required present considerable translational challenges. In this study we employed a combined protocol of optical and electrical stimulation to the sciatic nerve in an optogenetic mouse model to allow for better selectivity, efficiency, and safety to overcome fundamental limitations of electrical-only and optical-only stimulation.
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    Magnetically coupled percutaneous connector for chronic electrical peripheral nerve stimulation and recording in awake rats.
    (IEEE, 2024-08-02) Matarazzo, Jerico V; Williams-Wynn, Daniel T; Fallon, James B; Payne, Sophie C
    A fast-growing field of neuroscience and medicine is the treatment of disease via electrical stimulation of the peripheral nervous system. Peripheral nerve stimulation delivers stimulation to nerves of the periphery where the target nerve can and is often located deep within the abdomen. Long-term preclinical animal models that demonstrate the safety and/or efficacy of electrical stimulation have predominantly used a skull mount to connect to neural interfaces. When targeting nerves of the extremities and abdomen, this mount location is less favourable due to its distance to the implant causing complications in surgery and to the longevity of the device in vivo.