Browsing by Author "MacIsaac, Richard J"

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    Stimulation parameters for directional vagus nerve stimulation.
    (Bioelectronic Medicine, 2023-07-18) Villalobos, Joel; Payne, Sophie C; Ward, Glenn M; Andrikopoulos, Sofianos; Hyakumura, Tomoko; MacIsaac, Richard J; Fallon, James B
    Autonomic nerve stimulation is used as a treatment for a growing number of diseases. We have previously demonstrated that application of efferent vagus nerve stimulation (eVNS) has promising glucose lowering effects in a rat model of type 2 diabetes. This paradigm combines high frequency pulsatile stimulation to block nerve activation in the afferent direction with low frequency stimulation to activate the efferent nerve section. In this study we explored the effects of the parameters for nerve blocking on the ability to inhibit nerve activation in the afferent direction. The overarching aim is to establish a blocking stimulation strategy that could be applied using commercially available implantable pulse generators used in the clinic.