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Title: Vagus nerve stimulation to treat inflammatory bowel disease: a chronic, preclinical safety study in sheep
Authors: Payne, Sophie
Burns, Owen
Stebbing, Martin
Thomas, Ross
de Silva, Angel
Sedo, Alicia
Weissenborn, Frank
Hyakumura, Tomoko
Huynh, Mario
May, Clive
Williams, Richard
Furness, John
Fallon, James
Shepherd, Robert
Keywords: Electrode array
Inflammatory bowel disease
Peripheral nerve
Vagus nerve stimulation
Issue Date: Feb-2019
Publisher: Future Medicine Ltd
Citation: Payne, S. C., O. Burns, M. J. Stebbing, R. Thomas, A. C. de Silva, A. Sedo, F. Wiessenborn, T. Hyakumura, M. Huynh, C. N. May, R. A. Williams, J. Furness, J. Fallon, and R. Shepherd. 2019. Vagus nerve stimulation to treat inflammatory bowel disease: a chronic, preclinical safety study in sheep. Bioelectronics in Medicine: [epub ahead of print].
Abstract: Aim: Electrical stimulation of the left cervical vagus nerve is a feasible therapy for inflammatory bowel disease (IBD). However, due to the location of the electrode placement, stimulation is often associated with side effects. Methods: We developed a cuff electrode array, designed to be implanted onto the vagus nerve of the lower thorax or abdomen, below branches to vital organs, to minimize off-target effects to stimulation. Results: Following chronic implantation and electrical stimulation, electrodes remained functional and neural thresholds stable, while there were minimal off-target affects to stimulation. No nerve damage or corrosion of stimulated electrodes was observed. Conclusion: This novel electrode array, located on the vagus nerve below branches to vital organs, is a safe approach for the treatment of inflammatory bowel disease.
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/332
Appears in Collections:Neurobionics Research Publications

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