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Title: Subthalamic Nucleus Deep Brain Stimulation Evokes Resonant Neural Activity
Authors: Sinclair, Nicholas
McDermott, Hugh
Bulluss, Kristian
Fallon, James
Perera, Thushara
Xu, San San
Brown, Peter
Thevathasan, Wesley
Keywords: Deep brain stimulation
Issue Date: May-2018
Publisher: Wiley Periodicals, Inc.
Citation: Sinclair, N. C., H. J. McDermott, K. J. Bulluss, J. B. Fallon, T. Perera, S. S. Xu, P. Brown, and W. Thevathasan. 2018. Subthalamic nucleus deep brain stimulation evokes resonant neural activity. Annals of neurology: [epub ahead of print].
Abstract: Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-specific biomarker is required to optimize therapy. Here, we show that DBS evokes a large-amplitude resonant neural response focally in the subthalamic nucleus. This response is greatest in the dorsal region (the clinically optimal stimulation target for Parkinson disease), coincides with improved clinical performance, is chronically recordable, and is present under general anesthesia. These features make it a readily utilizable electrophysiological signal that could potentially be used for guiding electrode implantation surgery and tailoring DBS therapy to improve patient outcomes.
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/298
ISSN: 0364-5134
Appears in Collections:Neurobionics Research Publications

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