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Title: Biocompatibility of Immobilized Aligned Carbon Nanotubes
Authors: Nayagam, David
Williams, Richard
Chen, Jun
Magee, Kylie
Irwin, Jennifer
Tan, Justin
Innis, Peter
Leung, Ronald
Finch, Sue
Williams, Chris
Clark, Graeme
Wallace, Gordon
Keywords: Carbon nanotubes
Chronic diseases
Biocompability
Implants
Issue Date: 2011
Publisher: Wiley
Citation: Nayagam, David A. X., Richard A. Williams, Jun Chen, Kylie A. Magee, Jennifer Irwin, Justin Tan, Peter Innis, Ronald T. Leung, Sue Finch, Chris E. Williams, Graeme M. Clark, and Gordon G. Wallace. 2011. Biocompatibility of immobilized aligned carbon nanotubes. Small. 7(8): 1035-42.
Abstract: In vivo host responses to an electrode-like array of aligned carbon nanotubes (ACNTs) embedded within a biopolymer sheet are reported. This biocompatibility study assesses the suitability of immobilized carbon nanotubes for bionic devices. Inflammatory responses and foreign-body histiocytic reactions are not substantially elevated when compared to negative controls following 12 weeks implantation. A fibrous capsule isolates the implanted ACNTs from the surrounding muscle tissue. Filamentous nanotube fragments are engulfed by macrophages, and globular debris is incorporated into the fibrous capsule with no further reaction. Scattered leukocytes are observed, adherent to the ACNT surface. These data indicate that there is a minimal local foreign-body response to immobilized ACNTs, that detached fragments are phagocytosed into an inert material, and that ACNTs do not attract high levels of surface fouling. Collectively, these results suggest that immobilized nanotube structures should be considered for further investigation as bionic components.
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/256
ISSN: 1613-6829
Appears in Collections:Other research publications

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