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Title: Enhanced auditory neuron survival following cell- based BDNF treatment in the deaf guinea pig
Authors: Pettingill, Lisa
Wise, Andrew
Geaney, Marilyn
Shepherd, Robert
Keywords: Alginates/pharmacology
Brain-Derived Neurotrophic Factor/pharmacology
Brain-Derived Neurotrophic Factor/therapeutic use
Cell Survival - drug effects
Cochlear Implantation
Cochlear Nerve - drug effects
Cochlear Nerve - pathology
Deafness - drug therapy
Deafness - pathology
Glucuronic Acid - pharmacology
Guinea Pigs
Hexuronic Acids - pharmacology
Neurons - drug effects
Neurons - pathology
Schwann Cells - drug effects
Schwann Cells - transplantation
Issue Date: 5-Apr-2011
Publisher: PLOS
Citation: Pettingill, L. N., Wise, A. K., Geaney, M. S., & Shepherd, R. K. (2011). Enhanced auditory neuron survival following cell-based BDNF treatment in the deaf guinea pig. PLoS ONE, 6(4), e18733.
Abstract: Exogenous neurotrophin delivery to the deaf cochlea can prevent deafness-induced auditory neuron degeneration, however, we have previously reported that these survival effects are rapidly lost if the treatment stops. In addition, there are concerns that current experimental techniques are not safe enough to be used clinically. Therefore, for such treatments to be clinically transferable, methods of neurotrophin treatment that are safe, biocompatible and can support long-term auditory neuron survival are necessary. Cell transplantation and gene transfer, combined with encapsulation technologies, have the potential to address these issues. This study investigated the survival-promoting effects of encapsulated BDNF over-expressing Schwann cells on auditory neurons in the deaf guinea pig. In comparison to control (empty) capsules, there was significantly greater auditory neuron survival following the cell-based BDNF treatment. Concurrent use of a cochlear implant is expected to result in even greater auditory neuron survival, and provide a clinically relevant method to support auditory neuron survival that may lead to improved speech perception and language outcomes for cochlear implant patients.
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/25
ISSN: 1932-6203
Appears in Collections:Bionic Hearing Research Publications

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