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Title: Second spatial derivative analysis of cortical surface potentials recorded in cat primary auditory cortex using thin film surface arrays: Comparisons with multi-unit data
Authors: Fallon, James
Irving, Sam
Pannu, Satinderpall
Tooker, Angela
Wise, Andrew
Shepherd, Robert
Irvine, Dexter
Keywords: Local field potentials
Cochlear implant
Cortical plasticity
Neural prosthesis
Sensorineural hearing loss
Issue Date: Apr-2016
Publisher: Elsevier Ltd.
Citation: Fallon, J. B., S. Irving, S. S. Pannu, A. C. Tooker, A. K. Wise, R. K. Shepherd, and D. R. Irvine. 2016. Second spatial derivative analysis of cortical surface potentials recorded in cat primary auditory cortex using thin film surface arrays: Comparisons with multi-unit data. Journal of Neuroscience Methods. 267: 14-20.
Abstract: BACKGROUND: Current source density analysis of recordings from penetrating electrode arrays has traditionally been used to examine the layer- specific cortical activation and plastic changes associated with changed afferent input. We report on a related analysis, the second spatial derivative (SSD) of surface local field potentials (LFPs) recorded using custom designed thin-film polyimide substrate arrays. RESULTS: SSD analysis of tone- evoked LFPs generated from the auditory cortex under the recording array demonstrated a stereotypical single local minimum, often flanked by maxima on both the caudal and rostral sides. In contrast, tone-pips at frequencies not represented in the region under the array, but known (on the basis of normal tonotopic organization) to be represented caudal to the recording array, had a more complex pattern of many sources and sinks. COMPARISON WITH EXISTING METHODS: Compared to traditional analysis of LFPs, SSD analysis produced a tonotopic map that was more similar to that obtained with multi-unit recordings in a normal-hearing animal. Additionally, the statistically significant decrease in the number of acoustically responsive cortical locations in partially deafened cats following 6 months of cochlear implant use compared to unstimulated cases observed with multi-unit data (p=0.04) was also observed with SSD analysis (p=0.02), but was not apparent using traditional analysis of LFPs (p=0.6). CONCLUSIONS: SSD analysis of surface LFPs from the thin-film array provides a rapid and robust method for examining the spatial distribution of cortical activity with improved spatial resolution compared to more traditional LFP recordings.
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/247
ISSN: 1872-678X (Electronic) 0165-0270 (Linking)
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