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Title: Gentamicin Applied to the Oval Window Suppresses Vestibular Function in Guinea Pigs
Authors: King, Elisha
Shepherd, Robert
Fallon, James
Brown, Daniel
Keywords: Gentamicin
Aminoglycoside
Vestibulotoxicity
Ototoxicity
Oval window
Stapes
Stapediovestibular joint
Annular ligament
Intratimpanic
Pharmacokinetics
Issue Date: Jan-2017
Publisher: Springer
Citation: King, E. B., Shepherd, R. K., Brown, D. J., and Fallon, J. B. (2017) Gentamicin Applied to the Oval Window Suppresses Vestibular Function in Guinea Pigs. J Assoc Res Otolaryngol
Abstract: Intratympanic gentamicin therapy is widely used clinically to treat the debilitating symptoms of Meniere's disease. Cochleotoxicity is an undesirable potential side effect of the treatment and the risk of hearing loss increases proportionately with gentamicin concentration in the cochlea. It has recently been shown that gentamicin is readily absorbed through the oval window in guinea pigs. The present study uses quantitative functional measures of vestibular and cochlea function to investigate the efficacy of treating the vestibule by applying a small volume of gentamicin onto the stapes footplate in guinea pigs. Vestibular and cochlea function were assessed by recording short latency vestibular evoked potentials in response to linear head acceleration and changes in hearing threshold, respectively, 1 and 2 weeks following treatment. Histopathology was analyzed in the crista ampullaris of the posterior semi-circular canal and utricular macula in the vestibule, and in the basal and second turns of the cochlea. In animals receiving gentamicin on the stapes footplate, vestibular responses were significantly suppressed by 72.7 % 2 weeks after treatment with no significant loss of hearing. This suggests that the vestibule can be treated directly by applying gentamicin onto the stapes footplate.
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/230
ISSN: Print ISSN 1525-3961 Online ISSN 1438-7573
Appears in Collections:Bionic Hearing Research Publications

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