DSpace

About the Bionics Institute

 

Bionics Institute Research Online >
Bionic Hearing >
Bionic Hearing Research Publications >


Title: Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea
Authors: Wise, Andrew
Tan, Justin
Wang, Yajun
Caruso, Frank
Shepherd, Robert
Keywords: auditory nerve
nanoparticles
cochlea
Issue Date: Oct-2016
Publisher: PloS One
Citation: Wise, A. K., Tan, J., Wang, Y., Caruso, F. and Shepherd, R.K. (2016). Improved auditory nerve survival with nanoengineered supraparticles for neurotrophin delivery into the deafened cochlea. Plos One, 11(10).
Abstract: Cochlear implants electrically stimulate spiral ganglion neurons (SGNs) in order to provide speech cues to severe-profoundly deaf patients. In normal hearing cochleae the SGNs depend on endogenous neurotrophins secreted by sensory cells in the organ of Corti for survival. SGNs gradually degenerate following deafness and consequently there is considerable interest in developing clinically relevant strategies to provide exogenous neurotrophins to preserve SGN survival. The present study investigated the safety and efficacy of a drug delivery system for the cochlea using nanoengineered silica supraparticles. In the present study we delivered Brain-derived neurotrophic factor (BDNF) over a period of four weeks and evaluated SGN survival as a measure of efficacy. Supraparticles were bilaterally implanted into the basal turn of cochleae in profoundly deafened guinea pigs. One ear received BDNF-loaded supraparticles and the other ear control (unloaded) supraparticles. After one month of treatment the cochleae were examined histologically. There was significantly greater survival of SGNs in cochleae that received BDNF supraparticles compared to the contralateral control cochleae (repeated measures ANOVA, p = 0.009). SGN survival was observed over a wide extent of the cochlea. The supraparticles were well tolerated within the cochlea with a tissue response that was localised to the site of implantation in the cochlear base. Although mild, the tissue response was significantly greater in cochleae treated with BDNF supraparticles compared to the controls (repeated measures ANOVA, p = 0.003). These data support the clinical potential of this technology particularly as the supraparticles can be loaded with a variety of therapeutic drugs.
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/221
ISSN: 1932-6203 (Electronic) 1932-6203 (Linking)
Appears in Collections:Bionic Hearing Research Publications

Files in This Item:

File Description SizeFormat
2016-Wise et al. improved auditory nerve survival.pdf2.34 MBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

DSpace Software Copyright © 2002-2010  Duraspace -