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Title: Inferior Colliculus Responses to Multichannel Microstimulation of the Ventral Cochlear Nucleus: Implications for Auditory Brainstem Implants
Authors: Shivdasani, Mohit
Mauger, Stefan
Rathbone, Graeme
Paolini, Antonio
Issue Date: 2008
Publisher: American Physiological Society
Citation: Shivdasani, M. N., Mauger, S. J., Rathbone, G. D., & Paolini, A. G. (2008). Inferior colliculus responses to multichannel microstimulation of the ventral cochlear nucleus: implications for auditory brain stem implants. Journal of neurophysiology, 99(1), 1-13.
Series/Report no.: 99;1
Abstract: Multichannel techniques were used to assess the frequency specificity of activation in the central nucleus of the inferior colliculus (CIC) produced by electrical stimulation of localized regions within the ventral cochlear nucleus (VCN). Data were recorded in response to pure tones from 141 and 193 multiunit clusters in the rat VCN and the CIC, respectively. Of 141 VCN sites, 126 were individually stimulated while recording responses in the CIC. A variety of CIC response types were seen with an increase in both electrical and acoustic stimulation levels. The majority of sites exhibited monotonic rate level types acoustically while spike rate saturation was achieved predominantly with electrical stimulation. In 20.6% of the 364 characteristic frequency aligned VCN-CIC pairs, the CIC sites did not respond to stimulation. In 26% of the 193 CIC sites, a high correlation was observed between acoustic tuning and electrical tuning obtained through VCN stimulation. A high degree of frequency specificity was found in 58% of the 118 lowest threshold VCN-CIC pairs. This was dependent on electrode placement within the VCN as a higher degree of frequency specificity was achieved with stimulation of medial, central and postero-lateral VCN regions than more antero-lateral regions. Broadness of acoustic tuning in the CIC played a role in frequency-specific activation. Narrowly tuned CIC sites showed the lowest degree of frequency specificity upon stimulation of the antero-lateral VCN regions. This data provides significant implications for Auditory Brainstem Implant electrode placement, current localization, power requirements and facilitation of information transfer to higher brain centers.
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/182
ISSN: 0022-3077
Appears in Collections:Bionic Hearing Research Publications

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