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Title: Tremor Reduction by Deep Brain Stimulation Is Associated With Gamma Power Suppression in Parkinson's Disease
Authors: Beudel, Martjin
Little, Simon
Pogosyan, Alek
Ashkan, Keyoumars
Foltynie, Thomas
Limousin, Patricia
Zrinzo, Ludvic
Hariz, Marwan
Bogdanovic, Marko
Cheeran, Binith
Green, Alexander
Aziz, Tipu
Thevathasan, Wesley
Brown, Peter
Keywords: Deep brain stimulation
mechanisms of action
Parkinson's disease
subthalamic nucleus
Issue Date: Jul-2015
Publisher: John Wiley and Sons
Citation: Beudel, M., S. Little, A. Pogosyan, K. Ashkan, T. Foltynie, P. Limousin, L. Zrinzo, M. Hariz, M. Bogdanovic, B. Cheeran, A. L. Green, T. Aziz, W. Thevathasan & P. Brown (2015). Tremor Reduction by Deep Brain Stimulation Is Associated With Gamma Power Suppression in Parkinson's Disease. Neuromodulation 18(5): 349-354.
Abstract: Objectives Rest tremor is a cardinal symptom of Parkinson's disease (PD), and is readily suppressed by deep brain stimulation (DBS) of the subthalamic nucleus (STN). The therapeutic effect of the latter on bradykinesia and rigidity has been associated with the suppression of exaggerated beta (13–30 Hz) band synchronization in the vicinity of the stimulating electrode, but there is no correlation between beta suppression and tremor amplitude. In the present study, we investigate whether tremor suppression is related to suppression of activities at other frequencies. Materials and Methods We recorded hand tremor and contralateral local field potential (LFP) activity from DBS electrodes during stimulation of the STN in 15 hemispheres in 11 patients with PD. DBS was applied with increasing voltages starting at 0.5 V until tremor suppression was achieved or until 4.5 V was reached. Results Tremor was reduced to 48.9% ± 10.9% of that without DBS once stimulation reached 2.5–3 V (t14 = −4.667, p < 0.001). There was a parallel suppression of low gamma (31–45 Hz) power to 92.5% ± 3% (t14 = −2.348, p = 0.034). This was not seen over a band containing tremor frequencies and their harmonic (4–12 Hz), or over the beta band. Moreover, low gamma power correlated with tremor severity (mean r = 0.43 ± 0.14, p = 0.008) within subjects. This was not the case for LFP power in the other two bands. Conclusions Our findings support a relationship between low gamma oscillations and PD tremor, and reinforce the principle that the subthalamic LFP is a rich signal that may contain information about the severity of multiple different Parkinsonian features.
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/170
Appears in Collections:Neurobionics Research Publications

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