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Title: Treating hearing disorders with cell and gene therapy
Authors: Gillespie, Lisa
Richardson, Rachael
Nayagam, Bryony
Wise, Andrew
Keywords: hearing loss
gene therapy
cell therapy
stem cell therapy
cochlear implant
Issue Date: Oct-2014
Publisher: IOP Publishing
Citation: Gillespie, L. N., R. T. Richardson, B. A. Nayagam and A. K. Wise (2014). Treating hearing disorders with cell and gene therapy. J Neural Eng 11(6): 065001.
Abstract: Hearing loss is an increasing problem for a substantial number of people and, with an aging population, the incidence and severity of hearing loss will become more significant over time. There are very few therapies currently available to treat hearing loss, and so the development of new therapeutic strategies for hearing impaired individuals is of paramount importance to address this unmet clinical need. Most forms of hearing loss are progressive in nature and therefore an opportunity exists to develop novel therapeutic approaches to slow or halt hearing loss progression, or even repair or replace lost hearing function. Numerous emerging technologies have potential as therapeutic options. This paper details the potential of cell- and gene-based therapies to provide therapeutic agents to protect sensory and neural cells from various insults known to cause hearing loss; explores the potential of replacing lost sensory and nerve cells using gene and stem cell therapy; and describes the considerations for clinical translation and the challenges that need to be overcome.
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/141
ISSN: 1741-2552 (Electronic) 1741-2552 (Linking)
Appears in Collections:Bionic Hearing Research Publications

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