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Title: neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications
Authors: Slater, Kyle
Sinclair, Nicholas
Nelson, Timothy
Blamey, Peter
McDermott, Hugh
Keywords: retinal prosthesis
neurostimulator
suprachoroidal
bionic vision
retinitis pigmentosa
electrode array
Issue Date: Jul-2015
Publisher: IEEE
Citation: Slater, K. D., N. C. Sinclair, T. S. Nelson, P. J. Blamey and H. J. McDermott (2015). neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications. IEEE Journal of Translational Engineering in Health and Medicine 3: e3800111.
Abstract: To evaluate the efficacy of a suprachoroidal retinal prosthesis, a highly configurable external neurostimulator is required. In order to meet functional and safety specifications, it was necessary to develop a custom device. A system is presented which can deliver charge-balanced, constant-current biphasic pulses, with widely adjustable parameters, to arbitrary configurations of output electrodes. This system is shown to be effective in eliciting visual percepts in a patient with approximately 20 years of light perception vision only due to retinitis pigmentosa, using an electrode array implanted in the suprachoroidal space of the eye. The flexibility of the system also makes it suitable for use in a number of other emerging clinical neurostimulation applications, including epileptic seizure suppression and closed-loop deep brain stimulation. Clinical trial registration number NCT01603576 (<uri xlink:href="www.clinicaltrials.gov" xlink:type="simple">www.clinicaltrials.gov</uri>).
URI: http://repository.bionicsinstitute.org:8080/handle/123456789/128
ISSN: 2168-2372
Appears in Collections:Bionic Vision Research Publications

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